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SIVcpz cross‐species transmission and viral evolution toward HIV‐1 in a humanized mouse model
Author(s) -
Curlin James,
Schmitt Kimberly,
RemlingMulder Leila,
Moriarty Ryan,
Stenglein Mark,
O'Connor Shelby,
Marx Preston,
Akkina Ramesh
Publication year - 2020
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12440
Subject(s) - humanized mouse , biology , virology , adaptation (eye) , transmission (telecommunications) , viral evolution , genome , human immunodeficiency virus (hiv) , mutation , genetics , evolutionary biology , gene , immune system , neuroscience , electrical engineering , engineering
HIV‐1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the human host. We followed the evolution of SIVcpz in humanized mice to mimic cross‐species transmission. Increasing viral loads, CD4 + T‐cell decline, and non‐synonymous mutations were seen in the entire genome reflecting viral adaptation.