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Adverse event following live attenuated chikungunya vaccine in a cynomolgus macaque with pre‐existing chronic hydrocephalus
Author(s) -
Peterson Tiffany A.,
MacLean Andrew G.,
RussellLodrigue Kasi E.,
Didier Peter J.,
Weaver Scott C.,
Roy Chad J.
Publication year - 2019
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12414
Subject(s) - subclinical infection , medicine , adverse effect , vaccination , hydrocephalus , pediatrics , chikungunya , abnormality , macaque , immunology , virology , surgery , psychiatry , virus , biology , neuroscience
A cynomolgus macaque ( Macaca fascicularis ) with a pre‐existing, undiagnosed, subclinical but severe cerebral hydrocephalus was enrolled in a study of long‐term immunogenicity of the IRES/CHIK vaccine. The animal began showing signs of neurological dysfunction post‐vaccination, which progressed and ultimately resulted in euthanasia. The underlying brain abnormality was revealed at necropsy and was subsequently investigated with gross and microscopic examination. This becomes the first reported case of an adverse event following administration of a live attenuated vaccine and suggests the possibility of an increased susceptibility risk of unwanted adverse outcome associated with vaccination in populations with pre‐existing conditions such as hydrocephalus.