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SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV‐2
Author(s) -
Schmitt Kimberly,
Curlin James,
Kumar Dipu Mohan,
RemlingMulder Leila,
Feely Stephanie,
Stenglein Mark,
O'Connor Shelby,
Marx Preston,
Akkina Ramesh
Publication year - 2018
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12380
Subject(s) - virology , simian immunodeficiency virus , human immunodeficiency virus (hiv) , humanized mouse , biology , progenitor cell , transmission (telecommunications) , virulence , adaptation (eye) , lentivirus , immunology , stem cell , genetics , viral disease , gene , immune system , neuroscience , electrical engineering , engineering
How SIV progenitors evolved into deadly HIV‐1 and HIV‐2 following initial cross‐species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV‐2. Increased viral virulence to human CD4 + T cells and adaptive genetic changes were observed during serial passages.