SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV‐2 | Zendy

Schmitt Kimberly | Zendy; Curlin James | Zendy; Kumar Dipu Mohan | Zendy; RemlingMulder Leila | Zendy; Feely Stephanie | Zendy; Stenglein Mark | Zendy; O'Connor Shelby | Zendy; Marx Preston | Zendy; Akkina Ramesh | Zendy

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SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV‐2

Author(s) -

Schmitt Kimberly,

Curlin James,

Kumar Dipu Mohan,

RemlingMulder Leila,

Feely Stephanie,

Stenglein Mark,

O'Connor Shelby,

Marx Preston,

Akkina Ramesh

Publication year - 2018

Publication title -

journal of medical primatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.31

H-Index - 42

eISSN - 1600-0684

pISSN - 0047-2565

DOI - 10.1111/jmp.12380

Subject(s) - virology , simian immunodeficiency virus , human immunodeficiency virus (hiv) , humanized mouse , biology , progenitor cell , transmission (telecommunications) , virulence , adaptation (eye) , lentivirus , immunology , stem cell , genetics , viral disease , gene , immune system , neuroscience , electrical engineering , engineering

How SIV progenitors evolved into deadly HIV‐1 and HIV‐2 following initial cross‐species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV‐2. Increased viral virulence to human CD4 + T cells and adaptive genetic changes were observed during serial passages.

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