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Characterization of glucose‐stimulated insulin release protocols in african green monkeys ( Chlorocebus aethiops)
Author(s) -
Liddie Shervin,
Okamoto Haruka,
Gromada Jesper,
Lawrence Matthew
Publication year - 2019
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12374
Subject(s) - impaired glucose tolerance , insulin , diabetes mellitus , african green monkey , medicine , endocrinology , glucose tolerance test , type 2 diabetes , insulin resistance , kidney
Background Management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. These studies assessed different methodologies for determining glucose tolerance in green monkeys. Methods Twenty‐eight African green monkeys between 4 and 24 years old underwent single or repeat intravenous glucose tolerance testing ( IVGTT ), oral glucose tolerance testing ( OGTT ), and/or graded glucose infusion testing. Results Geriatric monkeys exhibited glucose intolerance with impaired glucose‐stimulated insulin secretion following IVGTT . Repeat IVGTT and OGTT assessments were inconsistent. Monkeys with low glucose‐stimulated insulin secretion after graded glucose infusion exhibited elevated blood glucose levels. Conclusion IVGTT and graded glucose infusion protocols revealed differences in glucose tolerance among green monkeys at single time points, including age‐dependent differences suggestive of shifts in pancreatic beta‐cell functional capacity, but care should be applied to study design and the interpretation of data in the setting of longitudinal studies.