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Reported analgesic and anaesthetic administration to non‐human primates undergoing experimental surgical procedure: 2010‐2015
Author(s) -
Bertrand Henri Georges Michel Justin,
Sandersen Charlotte,
Flecknell Paul Andrew
Publication year - 2018
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12346
Subject(s) - medicine , ketamine , analgesic , anesthesia , buprenorphine , perioperative , general anaesthetic , regimen , isoflurane , intensive care medicine , general anaesthesia , surgery , opioid , receptor
Background The use of non‐human primates (NHPs) in research remains a major societal concern with public expectations that appropriate anaesthetics and analgesics are used to minimize any pain or distress caused to animals undergoing invasive procedures. A literature review was conducted to examine the reporting of anaesthesia and analgesia methods used in non‐human primates undergoing surgical procedures, with recovery from anaesthesia. Methods A total of 397 papers from peer‐review journals published between 2010 and 2015 were examined. Results Only 25.9% of papers reported the analgesic regimen used, with carprofen and buprenorphine the 2 most widely used agents. Reporting of the anaesthetic regimens was included in 49.9% of papers. Ketamine and isoflurane were the most frequently used anaesthetic agents. Conclusions Anaesthetic and analgesic regimens administered to NHPs remain poorly reported. This lack of detailed descriptions of protocols does little to reassure the public or regulatory authorities that appropriate high standards of perioperative care are employed.