Premium
Apnea induction for invasive lung function testing in infant olive baboons: Comparison of intravenous propofol versus hyperventilation
Author(s) -
Ivanov Vadim A.,
Wolf Roman F.,
Papin James F.,
Anderson Michael P.,
Hill Claude L.,
Welliver Robert C.
Publication year - 2018
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12306
Subject(s) - propofol , apnea , medicine , hyperventilation , anesthesia , pulmonary function testing , ventilation (architecture) , washout , respiratory system , mechanical engineering , engineering
Background In various types of pulmonary research, pulmonary function testing ( PFT ) is performed to quantify the severity of lung disease. Induction of apnea and positive pressure ventilation are required for accurate PFT measurements in non‐cooperative subjects. We compared two methods of apnea induction in infant olive baboons ( Papio anubis ). Methods Pulmonary function testing results were compared during apnea induced by hyperventilation ( CO 2 washout) vs. intravenous propofol (1 dose 10 mg/kg). PFT was evaluated using a hot‐wire pneumotachometer incorporated within an Avea ventilator in nine 1‐month‐old baboons. Results Propofol induced apnea faster and more reliably. In both groups, PFT values passed the statistical equivalence test and were not significantly different (Student's t ‐test). There was a trend toward less data variability after propofol administration. Conclusions Intravenous propofol was non‐inferior to CO 2 washout for apnea induction in infant olive baboons. Propofol induced apnea faster and more reliably and yielded less variable PFT results.