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Mauritian cynomolgus macaques with M3M4 MHC genotype control SIV mac251 infection
Author(s) -
Li Hongzhao,
Omange Robert W.,
Czarnecki Chris,
CorreiaPinto Jorge F.,
CrecenteCampo Jose,
Richmond Meika,
Li Lin,
SchultzDarken Nancy,
Alonso Maria J.,
Whitney James B.,
Plummer Francis A.,
Luo Ma
Publication year - 2017
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12300
Subject(s) - genotype , biology , simian immunodeficiency virus , virology , immunology , genetics , immune system , microbiology and biotechnology , gene
Background Understanding natural HIV control may lead to new preventative or therapeutic strategies. Several protective major histocompatibility complex ( MHC ) genotypes were found in humans and rhesus macaques. Here, we report a simian immunodeficiency virus ( SIV ) controller MHC genotype in Mauritian cynomolgus macaques ( MCM s). Methods Twelve MHC ‐genotyped MCM s were infected with SIV mac251 and monitored for viral loads and CD 4+ T‐cell counts. Results Two macaques with M3M4 genotype exhibited the lowest peak viral loads (log plasma SIV RNA copies/mL), nearly 3 logs lower than those in most macaques with other MHC haplotype combinations, and set point viral loads below the level of detection limit by RT ‐ qPCR (<2 log RNA copies/ mL ). They maintained healthy CD 4+ T‐cell counts of >500 cells/μL blood, while CD 4 counts in the vast majority of other macaques were below this level. Conclusions The M3M4 MHC genotype may confer enhanced control of SIV replication in MCM s.