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Hepatic expression of cytochrome P450 enzymes in non‐human primate species
Author(s) -
Uehara Shotaro,
Uno Yasuhiro,
Yamazaki Hiroshi
Publication year - 2017
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12288
Subject(s) - primate , cytochrome p450 , biology , zoology , microsome , enzyme , human liver , evolutionary biology , biochemistry , ecology
Cytochromes P450 (P450) largely remain to be characterized in great apes. Comparative immunochemical detection of drug metabolizing forms of P450s 1A, 2A, 2B, 2C, 2D, 2E, 2J, 3A, 4A, and 4F in liver microsomes from chimpanzees, gorillas, orangutans, gibbons, cynomolgus and rhesus macaques, and common marmosets were carried out.