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SNP ‐based genetic characterization of the Tulane National Primate Research Center's conventional and specific pathogen‐free rhesus macaque ( Macaca mulatta ) populations
Author(s) -
Kanthaswamy Sree,
Ng Jillian,
Oldt Robert F.,
PhillippiFalkenstein Kathrine,
Kubisch H. Michael
Publication year - 2018
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12284
Subject(s) - rhesus macaque , macaque , biology , primate , genetic diversity , snp , evolutionary biology , genetic variation , genetics , nonhuman primate , single nucleotide polymorphism , genotype , population , gene , demography , ecology , sociology
Background The rhesus macaque is an important biomedical model organism, and the Tulane National Primate Research Center ( TNPRC ) has one of the largest rhesus macaque breeding colonies in the United States. Methods SNP profiles from 3266 rhesus macaques were used to examine the TNPRC colony genetic composition over time and across conventional or SPF animals of Chinese and Indian ancestry. Results Chinese origin animals were the least genetically diverse and the most inbred; however, since their derivation from their conventional forebearers, neither the Chinese nor the Indian SPF animals exhibit any significant loss of genetic diversity or differentiation. Conclusions The TNPRC colony managers have successfully minimized loss in genetic variation across generations. Although founder effects and bottlenecks among the Indian animals have been successfully curtailed, the Chinese subpopulation still show some influences from these events.