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Thrombotic thrombocytopenic purpura related to ADAMTS 13 deficiency, and successful treatment in a chimpanzee ( Pan troglodytes verus)
Author(s) -
Bolhuis Hester,
Wolters Marno,
Boer Mark,
Fijnheer Rob,
Zijll Langhout Martine,
Niphuis Henk,
Eckmann Carel
Publication year - 2017
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12278
Subject(s) - thrombotic thrombocytopenic purpura , prednisone , medicine , purpura (gastropod) , troglodytes , immunology , disease , platelet , biology , ecology
A 27‐year‐old male chimpanzee ( Pan troglodytes verus ) developed signs of thrombotic thrombocytopenic purpura ( TTP ). ADAMTS 13 deficiency appeared to be the cause of disease. After treatment with high‐dose prednisone, haematological values and clinical signs recovered. This is the first description of spontaneous TTP associated with ADAMTS 13 deficiency in a non‐human primate.