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Combination of kinematic analyses and diffusion tensor tractrography to evaluate the residual motor functions in spinal cord‐hemisected monkeys
Author(s) -
Zhao Can,
Song Wei,
Rao JiaSheng,
Zhao Wen,
Wei RuiHan,
Zhou Xia,
Tian PengYu,
Yang ZhaoYang,
Li XiaoGuang
Publication year - 2017
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12276
Subject(s) - kinematics , spinal cord , diffusion mri , anatomy , residual , tensor (intrinsic definition) , medicine , neuroscience , physics , biology , mathematics , geometry , classical mechanics , magnetic resonance imaging , radiology , algorithm
Background Spinal cord injury ( SCI ) causes loss of locomotor functions. Nowadays, the relationship between the residual locomotion after SCI and the diffusion tensor tractography ( DTT ) results still remains unclear. Methods Four rhesus monkeys were suffered thoracic cord hemisection. Kinematic evaluation and DTT were performed prior‐ and post‐ SCI (6 and 12 weeks). The longitudinal changes of gait parameters and the DTT parameters were analyzed for the injury‐contralateral hindlimb. The correlations between gaits and DTT parameters were also investigated. Results Almost gait parameters significantly changed after SCI , meanwhile, the caudal‐rostral connection rate of DTT showed negative correlation with all gait parameters, demonstrating that the locomotor changes of the injury‐contralateral hindlimb were associated with the ratio of residual fibers. Conclusions The combinatory use of gait analysis and DTT has been demonstrated to be sensitive to locomotion changes after SCI , and may therefore have potential applications in the pre‐clinical studies of SCI .