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Spontaneous telangiectatic osteosarcoma in a rhesus macaque ( Macaca mulatta )
Author(s) -
Goldschmidt B.,
Calado M.I.Z.,
Resende F.C.,
Caldas R.M.,
Pinto L.W.,
Lopes C.A.A.,
França F.G.O.,
Meireles B.S.,
Souza I.V.
Publication year - 2017
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12254
Subject(s) - osteosarcoma , pathology , epiphysis , medicine , bone marrow , diaphysis , rhesus macaque , anatomy , femur , surgery , immunology
Osteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4‐year‐old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Radiography revealed fracture and disorganized structure of bone tissue. Histopathological examination revealed malignant neoplasm composed of anaplastic osteoblasts, which invaded the bone marrow and surrounded blood‐filled cysts in the epiphysis and diaphysis forming septa. Cytogenetic analysis showed aneuploid cells, supernumerary Ag NOR s, and a marker fragment. The neoplasm was diagnosed as TO. To our knowledge, the occurrence of TO and its cytogenetic analysis were reported for the first time in non‐human primates.