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Spontaneous mediastinal myeloid sarcoma in a common marmoset ( Callithrix jacchus ) and review of the veterinary literature
Author(s) -
Morosco Danielle T.,
Cline Curtis R.,
Owston Michael A.,
Kumar Shyamesh,
Dick Edward J.
Publication year - 2017
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12253
Subject(s) - myeloid sarcoma , callithrix , marmoset , myeloid , pathology , biology , sarcoma , extramedullary hematopoiesis , myelopoiesis , haematopoiesis , medicine , immunology , stem cell , paleontology , genetics
Background Myeloid sarcoma is a rare manifestation of myeloproliferative disorder defined as an extramedullary mass composed of myeloid precursor cells. A 9‐month old, female, common marmoset ( Callithrix jacchus ) had increased respiratory effort. Methods A complete necropsy with histology and immunohistochemistry was performed. Results The thymus was replaced by a firm, gray‐tan mass with a faint green tint, filling over 50% of the thoracic cavity. Sheets of granulocytes, lymphoid cells, nucleated erythrocytes, megakaryocytes, and hematopoietic precursors of indeterminate cell lineage replaced the thymus, perithymic connective tissue, mediastinal adipose tissues, epicardium, and much of the myocardium. The cells demonstrated diffuse strong cytoplasmic immunoreactivity for lysozyme, and strong, multifocal membranous immunoreactivity for CD 117. Conclusion We report the first case of a myeloid sarcoma in a common marmoset ( C. jacchus ), similar to reported human cases of mediastinal myeloid sarcoma, and present a review of myeloproliferative diseases from the veterinary literature.