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Immunocytochemical localization of kisspeptin and kisspeptin receptor in the primate testis
Author(s) -
Irfan Shahzad,
Ehmcke Jens,
Shahab Muhammad,
Wistuba Joachim,
Schlatt Stefan
Publication year - 2016
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12212
Subject(s) - kisspeptin , biology , marmoset , endocrinology , sertoli cell , medicine , immunocytochemistry , receptor , spermatogenesis , hypothalamus , paleontology , biochemistry
Background Hypothalamic kisspeptin–kisspeptin receptor signalling in primates ensures the successful progression into puberty during development and maintenance of reproductive capacity during adulthood. Human testis has been shown to express high‐to‐moderate levels of kisspeptin and kisspeptin receptor gene expression. In this study, we aimed at characterizing the localization of kisspeptin and kisspeptin receptor in adult primate testis tissue. Methods Immunocytochemistry was performed on paraffin‐embedded testicular sections from adult rhesus monkeys and from common marmoset monkeys. Results Kisspeptin receptor was detected in Sertoli cells in the periphery of the seminiferous tubules in adult testes of both species. In contrast, kisspeptin was not localized in the seminiferous epithelium and was detected only in the interstitial compartment of the adult rhesus monkey testis. Conclusion Kisspeptin receptor and kisspeptin are localized in the testis of Old World and New World primates.