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Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity
Author(s) -
Amaral Imbeloni Aline,
Canevese Rahal Sheila,
Silva Filho Ednaldo,
Mendonça Faria Bianca,
Bandeira da Silva Wellington,
Guimarães Oliveira Karol,
Aihara Mika Ester,
Barros Monteiro Frederico Ozanan
Publication year - 2016
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12201
Subject(s) - osteocalcin , captivity , medicine , endocrinology , parathyroid hormone , biology , calcium , ecology , biochemistry , alkaline phosphatase , enzyme
Background The objective was to evaluate the procollagen type I N‐propeptide ( PINP ), osteocalcin ( OC ), β‐crosslaps (β‐ CTX ), and parathyroid hormone ( PTH ) in relation to age and sex of Chlorocebus aethiops in captivity. Methods Seventy‐three monkeys were divided into four age groups: AG 1 (juvenile); AG 2 (young adult); AG 3 (adult); and AG 4 (senile). An electrochemiluminescence immunoassay with an Elecsys 2010 analyzer was used to determine the serum markers of bone. Results and conclusions Sex did not influence the results of the markers. However, the variables PINP , OC , and β‐ CTX were negatively correlated with age (r = −0.643; r = −0.711; r = −0.488; P < 0.001, respectively), and PTH was correlated positively with age (r = 0.418, P < 0.001). The data obtained can be used as biomarkers of bone metabolism reference intervals in healthy C. aethiops in captivity.