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Development of SHIV s with circulating, transmitted HIV ‐1 variants
Author(s) -
Sharma Amit,
Boyd David F.,
Overbaugh Julie
Publication year - 2015
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12179
Subject(s) - human immunodeficiency virus (hiv) , transmission (telecommunications) , rhesus macaque , pathogenesis , immunology , macaque , virology , hiv vaccine , medicine , microbicides for sexually transmitted diseases , computational biology , biology , computer science , neuroscience , health services , telecommunications , vaccine trial , population , environmental health
SHIV /macaque model is critical for pre‐clinical HIV ‐1 research. The ability of this model to predict efficacious intervention(s) in humans depends on how faithfully the model recapitulates key features of HIV ‐1 transmission and pathogenesis. Here, we provide insights for rationally designing SHIV s with transmitted HIV ‐1 variants for vaccine and prevention research.