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Failure of heterogeneous amyloid‐enhancing factor in geriatric squirrel monkeys ( S aimiri boliviensis )
Author(s) -
Murakami Tomoaki,
Ibi Kanata,
Kuraishi Takeshi,
Hattori Shosaku,
Kai Chieko,
Ishiguro Naotaka,
Yanai Tokuma
Publication year - 2014
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12136
Subject(s) - squirrel monkey , amyloidosis , amyloid (mycology) , primate , stimulation , amyloid fibril , medicine , pathology , biology , amyloid β , neuroscience , anatomy , disease
Background Cross‐species transmission of AA amyloidosis between primates and other animals has not been previously reported. Methods Eight geriatric squirrel monkeys were intravenously administered chimpanzee, bovine, or chicken amyloid fibrils and simultaneously received inflammatory stimulation. Results AA amyloid deposition was not detected in any of the monkeys histopathologically or immunohistochemically. Conclusions These results suggest that heterogeneous AA amyloidosis may not be easily transmitted into primates.