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Large‐scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques ( M acaca mulatta )
Author(s) -
Kanthaswamy Sree,
Reader Rachel,
Tarara Ross,
Oslund Karen,
Allen Mark,
Ng Jillian,
Grinberg Chloe,
Hyde Dallas,
Smith David G.,
Lerche Nicholas
Publication year - 2014
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12127
Subject(s) - hypertrophic cardiomyopathy , biology , founder effect , cardiomyopathy , thickening , genetics , medicine , genotype , gene , heart failure , haplotype , biochemistry , chemistry , polymer science
Background Hypertrophic cardiomyopathy ( HCM ) is the abnormal thickening of the ventricles and an increase in cardiac mass. Methods Pedigree analyses involving 108 rhesus macaques with pronounced HCM were performed. Results Analyses revealed a strong genetic predisposition to this disease. Conclusions Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically, and anatomically.