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Preclinical evaluation of the immunomodulatory lymphocyte trafficking drug FTY 720 for HIV prevention in the female genital mucosa of macaques
Author(s) -
Morris Monica,
Aubert Rachael D.,
Butler Katherine,
Henning Tara,
Mitchell James,
Jenkins Leecresia,
Garber David,
McNicholl Janet,
Kersh Ellen N.
Publication year - 2014
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12120
Subject(s) - immunology , immune system , sex organ , human immunodeficiency virus (hiv) , drug , medicine , lymphocyte , transmission (telecommunications) , biology , pharmacology , genetics , electrical engineering , engineering
FTY720 has been shown to reduce inflammatory cytokines and immune cells in the genital mucosa of macaques. This pilot study examined the ability of FTY720 to inhibit HIV acquisition. Systemic treatment with FTY720 failed to prevent or delay vaginal SHIV transmission.