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Impaired development of fetal serotonergic neurons in intrauterine growth restricted baboons
Author(s) -
Ye Wenrui,
Xie Lynn,
Li Cun,
Nathanielsz Peter W.,
Thompson Brent J.
Publication year - 2014
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12116
Subject(s) - serotonergic , baboon , intrauterine growth restriction , offspring , fetus , endocrinology , medicine , primate , biology , physiology , pregnancy , serotonin , neuroscience , genetics , receptor
Background Famine and poor maternal nutrition have been associated with an increased risk for offspring developing psychiatric disorders later in life. Interestingly, impaired serotonergic signaling has been implicated in the etiology of multiple psychiatric conditions. Methods We studied development of the fetal serotonergic central nervous system in a baboon, non‐human primate model of intrauterine growth restriction ( IUGR ). Results and Conclusions Fetal (90% of full‐term) IUGR brains were comparable in size to controls, but have reduced expression of serotonergic proteins and mRNA s, as well as having fewer serotonergic neurons.