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PAS ‐positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque
Author(s) -
Hong Jung Joo,
Villinger Francois,
Courtney Cynthia L
Publication year - 2014
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12109
Subject(s) - rhesus macaque , germinal center , extracellular , macaque , biology , immunology , virology , microbiology and biotechnology , neuroscience , antibody , b cell
Background Lymphoid tissue remodeling is characteristic of chronic simian immunodeficiency virus infection. Methods A rhesus macaque infected with SIV mac239 was necropsied and its lymphoid tissues subjected to histopathology characterization. Results Germinal centers in spleen and lymph nodes contained PAS ‐positive, non‐amyloid extracellular deposits, decreased T follicular helper cells, and normal density of K i67 + B cells. Conclusions A possible mechanism for PAS ‐positive deposits includes exaggerated involution of SIV ‐induced follicular hyperplasia secondary to virus‐associated immune reaction.