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Numerical chromosome disorders in the common marmoset ( Callithrix jacchus ) – comparison between two captive colonies
Author(s) -
Delimitreva S.,
Wedi E.,
Bakker J.,
Tkachenko O.Y.,
Nikolova V.,
Nayudu P.L.
Publication year - 2013
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12050
Subject(s) - marmoset , callithrix , endoreduplication , biology , bone marrow , karyotype , anthonomus , chromosome , ploidy , immunology , genetics , ecology , curculionidae , gene
Background Chromosomal analyses were performed for marmosets from two colonies – D eutsches P rimatenzentrum ( DPZ ) and Biomedical Primate Research Centre ( BPRC ). Chlorine‐based disinfectants are used in DPZ ; no chemical disinfection is applied in BPRC . Methods The rates of chromosomal non‐disjunction, polyploidy and endoreduplication were investigated after G‐banding. Results For DPZ monkeys, the mean rates of non‐disjunction were 7.6% for bone marrow and 11.3% for lymphocytes. The polyploidy level was 2.5% in bone marrow and 0.8% in blood. Frequency of endoreduplication in bone marrow and in leucocytes was 0.5% and 0.8%, respectively. For BPRC , the rate of non‐disjunction in leucocytes (1.3%) was significantly lower than that for DPZ ; the polyploidy rate (0.2%) in blood was lower than that in DPZ ; endoreduplication was not observed. Conclusion The levels of chromosomal disorders are elevated for DPZ colony. We suggest that the increased rate of chromosomal disorders in DPZ marmosets can be related to the chemical disinfection of their environment.