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The genetic composition of populations of cynomolgus macaques ( M acaca fascicularis ) used in biomedical research
Author(s) -
Kanthaswamy S.,
Ng J.,
Satkoski Trask J.,
George D.A.,
Kou A.J.,
Hoffman L.N.,
Doherty T.B.,
Houghton P.,
Smith D.G.
Publication year - 2013
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12043
Subject(s) - biology , genetic diversity , allele , kinship , population , founder effect , genetic variation , genetics , evolutionary biology , zoology , gene , haplotype , demography , sociology , political science , law
Background The genetic composition of cynomolgus macaques used in biomedical research is not as well‐characterized as that of rhesus macaques. Methods Populations of cynomolgus macaques from S umatra, C orregidor, M auritius, S ingapore, C ambodia, and Z amboanga were analyzed using 24 STR s. Results The S umatran and C ambodian populations exhibited the highest allelic diversity, while the M auritian population exhibited the lowest. Sumatran cynomolgus macaques were the most genetically similar to all others, consistent with an I ndonesian origin of the species. The high diversity among C ambodian animals may result from interbreeding with rhesus macaques. The P hilippine and M auritian samples were the most divergent from other populations, the former due to separation from the S unda S helf by deepwater and the latter due to anthropogenic translocation and extreme founder effects. Conclusions Investigators should verify their research subjects' origin, ancestry, and pedigree to minimize risks to biomedical experimentation from genetic variance stemming from close kinship and mixed ancestry as these can obscure treatment effects.