Premium
Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus
Author(s) -
Jin Xi,
Zeng Li,
Zhang Shuang,
He Sirong,
Ren Yan,
Chen Younan,
Wei Lingling,
Wang Li,
Li Hongxia,
Cheng Jingqiu,
Lu Yanrong
Publication year - 2013
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12025
Subject(s) - insulin , medicine , diabetes mellitus , glycemic , islet , endocrinology , transplantation , adverse effect
Background Monkeys with insulin‐dependent diabetes are important preclinical animal models for islet transplantation. Exogenous insulin should be administered to achieve good glycemic control and minimize the long‐term vascular complications associated with diabetes until the graft function recovered completely. However, the effect of multiple daily injections of porcine or human insulin and the long‐term effects of porcine insulin have not been studied in diabetic rhesus monkeys. Methods Diabetic rhesus monkeys, using a 6‐month self‐control insulin comparison experiment, were used to detect the incidence of adverse events and long‐term diabetes complication events after long‐term administration of porcine insulin. Results In this study, we found that a 20% higher dose of porcine insulin results in similar glycemic control as the human insulin regimen, and adverse events were seldom reported when porcine insulin was administered. Moreover, long‐term injection with porcine insulin could delay the rate and severity of diabetes‐related complications. Conclusions Porcine insulin as a competent candidate for regular insulin therapy to maintain blood glucose levels in insulin‐dependent diabetic monkeys during preclinical studies of islet transplantation.