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Innate immune responses to TLR 2 and TLR 4 agonists differ between baboons, chimpanzees and humans
Author(s) -
Brinkworth J.F.,
Pechenkina E.A.,
Silver J.,
Goyert S.M.
Publication year - 2012
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12002
Subject(s) - baboon , chemokine , agonist , cytokine , tlr4 , biology , tlr2 , innate immune system , immunology , immune system , papio anubis , receptor , endocrinology , biochemistry
Background African catarrhine primates differ in bacterial disease susceptibility. Methods Human, chimpanzee, and baboon blood were stimulated with TLR ‐detected bacterial agonists and cytokine/chemokine induction assessed by real‐time PCR . Results Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent. Conclusions These primates tend to generate species rather than agonist‐specific responses to bacterial agonists.