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Relationships of social support, health‐promoting lifestyles, glycemic control, and bone turnover among adults with type 2 diabetes
Author(s) -
Ha Mei,
Chen Jun,
Zhang Xiaojuan,
Yang Hong,
Liu Changjiang
Publication year - 2020
Publication title -
japan journal of nursing science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.363
H-Index - 17
eISSN - 1742-7924
pISSN - 1742-7932
DOI - 10.1111/jjns.12280
Subject(s) - medicine , glycemic , bone remodeling , n terminal telopeptide , glycated hemoglobin , procollagen peptidase , type 2 diabetes mellitus , endocrinology , osteoporosis , type 2 diabetes , bone resorption , diabetes mellitus , gerontology , physiology , alkaline phosphatase , osteocalcin , biology , biochemistry , enzyme
Aim There is increasing evidence that hyperglycemia, oxidative stress, and the accumulation of advanced glycation end products in type 2 diabetes mellitus (T2DM) can lead to the deterioration of bone remodeling. The purpose of this study was to explore relationships of social support, health‐promoting lifestyles, glycated hemoglobin (HbA1c) levels, and serum bone turnover markers (BTMs, including procollagen type I amino‐terminal propeptide [PINP] and β‐isomerised carboxy‐terminal cross‐linking telopeptide of type I collagen [β‐CTX]) among individuals with T2DM. Methods A total of 175 subjects were recruited by convenience sampling and divided into three groups based on their HbA1c levels. Statistical strategies of Spearman's correlation coefficient and multiple linear regression were used in this cross‐sectional study. Results There was a positive association between PINP and β‐CTX, whereas the HbA1c level was inversely correlated with BTMs. Moreover, scores of both PINP and β‐CTX were different in genders, males having lower levels of BTMs than females after adjustment for weight. Furthermore, both social support and health‐promoting lifestyles were negatively correlated with HbA1c levels, whereas they did not significantly relate to declines in PINP and β‐CTX. Conclusion High HbA1c levels detrimentally influence bone formation and bone resorption, and males with T2DM might be more susceptible to osteoporosis because of their relatively lower levels of BTMs. However, s ocial support and health‐promoting lifestyles could contribute to better glycemic control.