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Risk factors for mortality in D own syndrome
Author(s) -
Uppal H.,
Chandran S.,
Potluri R.
Publication year - 2015
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/jir.12196
Subject(s) - medicine , population , dementia , relative risk , risk factor , pneumonia , respiratory failure , pediatrics , disease , confidence interval , environmental health
Background D own syndrome is a genetic condition that contributes to a significantly shorter life expectancy compared with the general population. We investigated the most common comorbidities in a population of acute hospital patients with D own syndrome and further explored what the most common risk factors for mortality are within this population. Method From our database of one million patients admitted to N ational H ealth S ervice ( NHS ) T rusts in northern E ngland, we identified 558 people who had D own syndrome. We compared this group with an age‐ and gender‐matched control group of 5580 people. Results The most prevalent comorbid diseases within the D own's population were hypothyroidism (22.9%) and epilepsy (20.3%). However, the conditions that had the highest relative risks ( RR s) in the D own's population were septal defects and dementia. Respiratory failure, dementia and pneumonia were the most significantly related comorbidities to mortality in the D own syndrome population. In the control population, respiratory failure, dementia and renal failure were the most significant disease contributors. When these contributors were analysed using multivariate analysis, heart failure, respiratory failure, pneumonia and epilepsy were the identified risk factors for in‐hospital mortality in the D own syndrome population. Respiratory failure was the sole risk factor for mortality in the D own syndrome population [ RR = 9.791 (1.6–59.9) P ≤ 0.05], when compared with the risk factors for mortality in the control population. Conclusions There is significant medical morbidity in D own syndrome. This morbidity contributes to the lower life expectancy. Respiratory failure is a risk factor for mortality in D own syndrome. We need to thoroughly investigate people with D own syndrome to ensure any treatable illnesses are well managed.