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Aerobic training improved low‐grade inflammation in obese women with intellectual disability
Author(s) -
Ordonez F. J.,
Rosety M. A.,
Camacho A.,
Rosety I.,
Diaz A. J.,
Fornieles G.,
Garcia N.,
RosetyRodriguez M.
Publication year - 2014
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/jir.12056
Subject(s) - aerobic exercise , medicine , body mass index , obesity , inflammation , metabolic syndrome , endocrinology , nephelometry , physical therapy , immunology , antibody
Background Obesity is a major health problem in people with intellectual disabilities. It is also widely accepted that low‐grade systemic inflammation associated to obesity plays a key role in the pathogenic mechanism of several disorders. Fortunately, physical activity has shown to improve inflammation in people with metabolic syndrome and type 2 diabetes. Accordingly, we assessed the influence of aerobic training on pro‐inflammatory cytokines and acute phase proteins in women with D own syndrome. Methods To achieve this outcome, 20 premenopausal obese young women with D own syndrome volunteered for this study. Eleven were randomly assigned to the intervention group and performed a 10‐week aerobic training programme, three sessions per week, consisting of a warm‐up then a 30‐ to 40‐min treadmill exercise at a work intensity of 55–65% of peak heart rate followed by a cooling‐down period. The control group included nine age‐, sex‐ and body mass index‐matched women with D own syndrome. Fat mass percentage and fat distribution were measured. Plasmatic levels of tumour necrosis factor ( TNF )‐α, interleukin ( IL )‐6 and fibrinogen were assessed by commercial enzyme‐linked immunosorbent assay kits. C ‐reactive protein ( CRP ) was assessed by nephelometry. Results Plasmatic levels of TNF ‐α (11.7 ± 1.6 vs. 9.2 ± 1.3 pg/ml; P = 0.022), IL ‐6 (8.2 ± 1.1 vs. 6.1 ± 0.9 pg/ml; P = 0.014) and high sensitive CRP (0.62 ± 0.11 vs. 0.53 ± 0.09 mg/dl; P = 0.009) were significantly reduced in the intervention group. Further, significant correlations between plasmatic and anthropometric parameters were found. Conclusion A 10‐week training programme reduced pro‐inflammatory cytokines and acute phase proteins in obese young women with D own syndrome. Long‐term, well‐conducted studies are still required to determine whether correction of this low‐grade inflammation improves clinical outcomes of women with trisomy 21.