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Cover Image: Plant synthetic biology
Publication year - 2018
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/jipb.12753
Subject(s) - computational biology , aptamer , cas9 , biology , nuclease , dna , cover (algebra) , epigenetics , crispr , sequence (biology) , genome , base pair , genetics , gene , mechanical engineering , engineering
The nuclease domain of Cas9 can be deactivated by point mutations, to convert the protein into a sequence‐specific DNA‐binding protein. In this issue, Kumlehn et al. (1127–1153) discuss the use of the resultant deactivated Cas9 protein to target various functions by binding to specific sites in genome for applications, such as imaging, epigenetic and transcriptional regulation, base editing or aptamer fusions.