Essential role of  NbNOG1  in ribosomal RNA processing | Zendy

Guo Jiangbo | Zendy; Han Shaojie | Zendy; Zhao Jinping | Zendy; Xin Cuihua | Zendy; Zheng Xiyin | Zendy; Liu Yule | Zendy; Wang Yan | Zendy; Qu Feng | Zendy

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Essential role of NbNOG1 in ribosomal RNA processing

Author(s) -

Guo Jiangbo,

Han Shaojie,

Zhao Jinping,

Xin Cuihua,

Zheng Xiyin,

Liu Yule,

Wang Yan,

Qu Feng

Publication year - 2018

Publication title -

journal of integrative plant biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.734

H-Index - 83

eISSN - 1744-7909

pISSN - 1672-9072

DOI - 10.1111/jipb.12691

Subject(s) - ribosome biogenesis , biology , nicotiana benthamiana , ribosome , ribosomal rna , microbiology and biotechnology , biogenesis , yeast , ribosomal protein , rna , saccharomyces cerevisiae , genetics , gene

Summary Nucleolar GTP‐binding protein 1 (NOG1) is a highly conserved GTPase first reported in Trypanosoma as required for ribosome biogenesis. We characterized NbNOG1, a Nicotiana benthamiana NOG1 ortholog sharing more than 45% amino acid identity with Trypanosoma , yeast, and human NOG1. N. benthamiana plants silenced for NbNOG1 were stunted and produced sterile flowers. NbNOG1 is functionally interchangeable with yeast NOG1 (ScNOG1) , rescuing yeast lethality caused by loss of ScNOG1 . Finally, NbNOG1 silencing caused over‐accumulation of pre‐rRNA processing intermediates, and concomitant loss of mature rRNAs. Collectively, these data support a role for NbNOG1 in ribosomal RNA processing.

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