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BAK 1 Directly Regulates Brassinosteroid Perception and BRI 1 Activation
Author(s) -
He Kai,
Xu Shengbao,
Li Jia
Publication year - 2013
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/jipb.12122
Subject(s) - brassinosteroid , signal transduction , microbiology and biotechnology , ligand (biochemistry) , receptor , function (biology) , biology , kinase , mechanism (biology) , arabidopsis , mutant , biochemistry , gene , physics , quantum mechanics
Plants utilize plasma membrane‐localized receptor‐like kinases (RLKs) to sense extracellular signals to coordinate growth, development, and innate immune responses. BAK1 regulates multiple signaling pathways acting as a co‐receptor of several distinct ligand‐binding RLKs. It has been debated whether BAK1 serves as an essential regulatory component or only a signal amplifier without pathway specificity. This issue has been clarified recently. Genetic and structural analyses indicated that BAK1 and its homologs play indispensible roles in mediating brassinosteroid (BR) signaling pathway by directly perceiving the ligand BR and activating the receptor of BR, BRI1. The mechanism revealed by these studies now serves as a paradigm for how a pair of RLKs can function together in ligand binding and subsequent initiation of signaling.Jia Li (Corresponding author)