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Post‐lunch triglyceridaemia associates with HDL c and insulin resistance in fasting normotriglyceridaemic menopausal women
Author(s) -
SanzParis A.,
RodriguezValle A.,
Navarro M. A.,
PuzoFoncillas J.,
ArbonesMainar J. M.
Publication year - 2017
Publication title -
journal of human nutrition and dietetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 70
eISSN - 1365-277X
pISSN - 0952-3871
DOI - 10.1111/jhn.12476
Subject(s) - medicine , insulin resistance , endocrinology , triglyceride , menopause , insulin , homeostatic model assessment , mediterranean diet , cholesterol
Objectives Post‐prandial hypertriglyceridaemia (P‐ HTG ) is associated with cardiovascular disease. This association is of paramount importance during menopause, which is also related to reduced high‐density lipoprotein ‐cholesterol ( HDL c) and elevated triglyceride ( TG ) levels. We aimed to provide a self‐assesing tool to screen for P‐ HTG in menopausal women who were normotriglyceridaemic at fasting and adhered to a Mediterranean‐style eating pattern. Methods We performed oral fat loading tests ( OFLT ) in combination with self‐measurements of diurnal capillary TG at fixed time‐points ( DC ‐ TG ) in 29 healthy menopausal women. TG levels >220 mg dL −1 at any given time during the OFLT served as diagnostic criteria for P‐ HTG . Subsequently, DC ‐ TG profiles were examined to determine the best mealtime (breakfast, lunch or dinner), as well as optimal cut‐off points to classify these women as having P‐ HTG according to the OFLT . Insulin resistance was defined as the upper tertile of the homeostatic model assessment of insulin resistance. Results We found that, despite having normal fasting TG levels, P‐ HTG was highly prevalent (approximately 40%). Moreover, self‐assessed 3‐h post‐lunch TG levels >165 mg dL −1 increased the odds of having hypo‐ HDL cholesterolaemia by 14.1‐fold ( P = 0.026) and the odds of having insulin resistance by 31.6‐fold ( P = 0.007), adjusted for total fat intake in women adhering to a Mediterranean eating pattern having their highest energy intake at lunch. Conclusions Self‐assessed 3‐h post‐lunch TG can be used to study post‐prandial TG metabolism in Southern European menopausal women who are normotriglyceridaemic at fasting. Characterising an individual's post‐prandial response may help menopausal women to evaluate their risk of cardiovascular disease.