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Using Healthcare Data in Embedded Pragmatic Clinical Trials among People Living with Dementia and Their Caregivers: State of the Art
Author(s) -
Bynum Julie P.W.,
Dorr David A.,
Lima Julie,
McCarthy Ellen P.,
McCreedy Ellen,
Platt Richard,
Vydiswaran V.G. Vinod
Publication year - 2020
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.16617
Subject(s) - collaboratory , dementia , medicine , gerontology , health care , leverage (statistics) , clinical trial , disease , population , alzheimer's disease , world wide web , computer science , environmental health , pathology , economics , economic growth , machine learning
Embedded pragmatic clinical trials (ePCTs) are embedded in healthcare systems as well as their data environments. For people living with dementia (PLWD), settings of care can be different from the general population and involve additional people whose information is also important. The ePCT designs have the opportunity to leverage data that becomes available through the normal delivery of care. They may be particularly valuable in Alzheimer's disease and Alzheimer's disease‐related dementia (AD/ADRD), given the complexity of case identification and the diversity of care settings. Grounded in the objectives of the Data and Technical Core of the newly established National Institute on Aging Imbedded Pragmatic Alzheimer's Disease and AD‐Related Dementias Clinical Trials Collaboratory (IMPACT Collaboratory), this article summarizes the state of the art in using existing data sources (eg, Medicare claims, electronic health records) in AD/ADRD ePCTs and approaches to integrating them in real‐world settings. J Am Geriatr Soc 68:S49–S54, 2020 .