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Circulating serum level of retinoic acid and hip fractures among postmenopausal women
Author(s) -
Li XiaoBin,
Liu Tao,
Fan Lei,
Gao Qiang,
Peng Qiang,
Cai Teng,
Wang LiMin
Publication year - 2019
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.15667
Subject(s) - medicine , odds ratio , hip fracture , confidence interval , subclinical infection , logistic regression , univariate analysis , postmenopausal women , multivariate analysis , gastroenterology , osteoporosis
PURPOSE The aim of this study was to evaluate the serum levels of retinoic acid (RA), an active form of vitamin A, in postmenopausal women with hip fractures from Zhengzhou, China. METHODS This was a case‐control study from the Affiliated Hospital of Zhengzhou University. Serum samples were drawn from 375 postmenopausal women who were diagnosed as having hip fracture and 750 matched controls without fracture. Serum RA levels were evaluated as both a continuous variable and a categorical variable in quintiles. RESULTS The results showed that the serum levels of RA were significantly ( P = .039) higher in patients with hip fracture compared with controls. In univariate and multivariate logistic regression analysis, for each 1 ng/mL increase of serum level of RA, the unadjusted and adjusted risk of hip fracture would be increased by 5% (odds ratio [OR] = 1.05; 95% confidence interval [CI] = 1.00‐1.10; P = .035) and 2% (OR = 1.02; 95% CI = 0.95‐1.11; P = .096), respectively. In multivariate models comparing the fifth with the third quintiles of RA, the RA was associated with hip fracture, and adjusted risk of hip fracture would be increased by 52% (OR = 1.52; 95% CI = 1.13‐1.42; P = .011). CONCLUSIONS The results of our study suggest that subclinical higher levels of RA may increase the risk of hip fracture in postmenopausal women, particularly among the top quintile of serum RA. J Am Geriatr Soc 67:336–341, 2019.