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Motor and Cognitive Trajectories Before Dementia: Results from Gait and Brain Study
Author(s) -
MonteroOdasso Manuel,
Speechley Mark,
MuirHunter Susan W.,
SarquisAdamson Yanina,
Sposato Luciano A.,
Hachinski Vladimir,
Borrie Michael,
Wells Jennie,
Black Alanna,
Sejdić Ervin,
Bherer Louis,
Chertkow Howard
Publication year - 2018
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.15341
Subject(s) - medicine , gait , dementia , physical medicine and rehabilitation , cognition , gerontology , physical therapy , psychiatry , disease
Objectives To compare the trajectories of motor and cognitive decline in older adults who progress to dementia with the trajectories of those who do not. To evaluate the added value of measuring motor and cognitive decline longitudinally versus cross‐sectionally for predicting dementia. Design Prospective cohort study with 5 years of follow‐up. Setting Clinic based at a university hospital in London, Ontario, Canada. Participants Community‐dwelling participants aged 65 and older free of dementia at baseline (N=154). Measurements We evaluated trajectories in participants' motor performance using gait velocity and cognitive performance using the MoCA test twice a year for 5 years. We ascertained incident dementia risk using Cox regression models and attributable risk analyses. Analyses were adjusted using a time‐dependent covariate. Results Overall, 14.3% progressed to dementia. The risk of dementia was almost 7 times as great for those whose gait velocity declined (hazard ratio (HR)=6.89, 95% confidence interval (CI)=2.18–21.75, p=.001), more than 3 times as great for those with cognitive decline (HR=3.61, 95% CI=1.28–10.13, p=.01), and almost 8 times as great in those with combined gait velocity and cognitive decline (HR=7.83, 95% CI=2.10–29.24, p=.002), with an attributable risk of 105 per 1,000 person years. Slow gait at baseline alone failed to predict dementia (HR=1.16, 95% CI=0.39–3.46, p=.79). Conclusion Motor decline, assessed according to serial measures of gait velocity, had a higher attributable risk for incident dementia than did cognitive decline. A decline over time of both gait velocity and cognition had the highest attributable risk. A single time‐point assessment was not sufficient to detect individuals at high risk of dementia.