Premium
Targeting Behavioral Symptoms and Functional Decline in Dementia: A Randomized Clinical Trial
Author(s) -
Gitlin Laura N.,
Arthur Paul,
Piersol Catherine,
Hessels Virginia,
Wu Samuel S.,
Dai Yunfeng,
Mann William C.
Publication year - 2018
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.15194
Subject(s) - medicine , dementia , randomized controlled trial , quality of life (healthcare) , caregiver burden , activities of daily living , family caregivers , motivational interviewing , clinical trial , physical therapy , gerontology , disease , nursing
Background/Objectives Dementia‐related behavioral symptoms and functional dependence result in poor quality of life for persons with dementia and their caregivers. The goal was to determine whether a home‐based activity program (Tailored Activity Program; TAP ‐ VA ) would reduce behavioral symptoms and functional dependence of veterans with dementia and caregiver burden. Design Single‐blind (interviewer), parallel, randomized, controlled trial (Clinicaltrials.gov: NCT 01357564). Setting Veteran's homes. Participants Veterans with dementia and their family caregivers (N = 160 dyads). Intervention Dyads in TAP ‐ VA underwent 8 sessions with occupational therapists to customize activities to the interests and abilities of the veterans and educate their caregivers about dementia and use of customized activity. Caregivers assigned to attention control received up to 8 telephone‐based dementia education sessions with a research team member. Measurements Primary outcomes included number of behaviors and frequency of their occurrence multiplied by severity of occurrence; secondary outcomes were functional dependence, pain, emotional well‐being, caregiver burden (time spent caregiving, upset with behaviors) and affect at 4 (primary endpoint) and 8 months. Results Of 160 dyads (n = 76 TAP ‐ VA ; n = 84 control), 111 completed 4‐month interviews (n = 51 TAP ‐ VA ; n = 60 control), and 103 completed 8‐month interviews (n = 50 TAP ‐ VA ; n = 53 control). At 4 months, compared to controls, the TAP ‐ VA group showed reductions in number (difference in mean change from baseline = −0.68, 95% CI = −1.23 to −0.13) and frequency by severity (−24.3, 95% CI = −45.6 to −3.1) of behavioral symptoms, number of activities needing assistance with (−0.80, 95% CI = −1.41 to −0.20), functional dependence level (4.09, 95% CI = 1.06, 7.13), and pain (−1.18, 95% CI = −2.10 to −0.26). Caregivers of veterans in TAP ‐ VA reported less behavior‐related distress. Benefits did not extend to 8 months. Conclusion TAP ‐ VA had positive immediate effects and no adverse events. Because TAP ‐ VA reduces behavioral symptoms, slows functional dependence, and alleviates pain and caregiver distress, it is a viable treatment option for families.