Premium
Hemoglobin Concentration Influences N‐Terminal Pro B‐Type Natriuretic Peptide Levels in Hospitalized Older Adults with and without Heart Failure
Author(s) -
Lelli Diana,
Antonelli Incalzi Raffaele,
Pedone Claudio
Publication year - 2017
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.14959
Subject(s) - medicine , natriuretic peptide , confounding , heart failure , hemoglobin , linear regression , retrospective cohort study , cardiology , machine learning , computer science
Objectives To investigate the relationship between hemoglobin and N‐terminal pro B‐type natriuretic peptide ( NT ‐pro BNP ) concentration in hospitalized older adults with or without a diagnosis of heart failure ( HF ). Design Cross‐sectional study based on retrospective hospital records review. Setting Geriatric acute care ward. Participants Individuals aged 65 and older (N = 226; mean age 81.1), with (n = 104) and without (n = 122) a diagnosis of HF . Measurements Information was collected on demographic characteristics, comorbidities, and laboratory and echocardiographic data. The relationship between hemoglobin and NT ‐pro BNP was evaluated using linear regression models adjusted for potential confounders. Results A negative association was found between NT ‐pro BNP and hemoglobin (β = −0.226, P < .001). The regression coefficient was −0.114 ( P = .04) in the subsample with HF and −0.191 ( P < .001) in the subsample without HF. After adjustment for potential confounders, the inverse association between hemoglobin and NT ‐pro BNP was confirmed in the whole sample (β = −0.182, P < .001), in those with HF (β = −0.136, P = .007), and in those without HF (β = −0.165, P = .003). Conclusion Hemoglobin concentration should be taken into account in the interpretation of NT ‐pro BNP in hospitalized older adults, especially those without HF .