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Falls and Frailty in Prostate Cancer Survivors: Current, Past, and Never Users of Androgen Deprivation Therapy
Author(s) -
WintersStone Kerri M.,
Moe Esther,
Graff Julie N.,
Dieckmann Nathan F.,
Stoyles Sydnee,
Borsch Carolyn,
Alumkal Joshi J.,
Amling Christopher L.,
Beer Tomasz M.
Publication year - 2017
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.14795
Subject(s) - medicine , androgen deprivation therapy , prostate cancer , odds ratio , gerontology , cancer , physical therapy
Objectives To compare the prevalence of and association between falls and frailty of prostate cancer survivors ( PCS s) who were current, past or never users of androgen deprivation therapy ( ADT ). Design Cross‐sectional. Setting Mail and electronic survey. Participants PCS s (N = 280; mean age 72 ± 8). Measurements Cancer history, falls, and frailty status (robust, prefrail, frail) using traditionally defined and obese phenotypes. Results Current (37%) or past (34%) ADT users were more than twice as likely to have fallen in the previous year as never users (15%) ( P = .002). ADT users had twice as many recurrent falls ( P < .001) and more fall‐related injuries than unexposed men ( P = .01). Current (43%) or past (40%) ADT users were more likely to be classified as prefrail or frail than never users (15%) ( P < .001), and the prevalence of combined obese frailty + prefrailty was even greater in current (59%) or past (62%) ADT users than never users (25%) ( P < .001). Traditional and obese frailty significantly increased the likelihood of reporting falls in the previous year (odds ratio ( OR ) = 2.15, 95% CI = 1.18–3.94 and OR = 2.97, 95% CI = 1.62–5.58, respectively) and was also associated with greater risk of recurrent falls ( OR = 3.10, 95% CI = 1.48–6.5 and OR = 3.99, 95% CI = 1.79–8.89, respectively). Conclusions Current and past exposure to ADT is linked to higher risk of falls and frailty than no treatment. PCS s should be appropriately counseled on fall prevention strategies, and approaches to reduce frailty should be considered.