Premium
Metformin‐SGLT2, Dehydration, and Acidosis Potential
Author(s) -
D'Elia John A.,
Segal Alissa R.,
Weinrauch Larry A.
Publication year - 2017
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.14724
Subject(s) - medicine , metformin , glycosuria , acidosis , type 2 diabetes , lactic acidosis , diabetes mellitus , renal function , diarrhea , dehydration , intensive care medicine , endocrinology , biochemistry , chemistry
Clinicians are aware of the risks and benefits of metformin in type 2 diabetes. In geriatric populations lactic acidosis due to diminishing kidney function is an issue. The recent addition of a group of agents to control diabetes through increased glycosuria may increase the risk of dehydration and acidosis. This may happen due to gastrointestinal loss from metformin diarrhea or urine loss from diuretics. A typical example is presented.