Premium
Effect of Resting Heart Rate on All‐Cause Mortality and Cardiovascular Events According to Age
Author(s) -
Li Kuibao,
Yao Chonghua,
Yang Xinchun,
Dong Lei
Publication year - 2017
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.14714
Subject(s) - medicine , proportional hazards model , quartile , prospective cohort study , cohort , cohort study , demography , gerontology , confidence interval , sociology
Objectives To examine whether the association between resting heart rate ( RHR ) and all‐cause mortality and cardiovascular events differs according to age. Design Prospective cohort. Setting Community in Beijing, China. Participants Individuals aged 40 and older without cardiovascular disease at baseline (N = 6,209). Measurements Trained investigators interviewed participants using a standard questionnaire to obtain information on demographic characteristics, medical history and lifestyle risk factors in 1991. RHR was evaluated according to quartiles (<72, 72–76, 76–84, ≥84 beats/min). Cox regression models were used to assess the associations between RHR and all‐cause mortality and cardiovascular events. Results During a mean follow‐up of 8.3 years, 840 subjects died, and 676 experienced a cardiovascular event. Higher RHR was significantly associated with all‐cause mortality ( P trend < .001) and cardiovascular events ( P trend = .002) in older (≥60) but not younger (<60) participants (both P trend > .05). There were significant modifying effects of age on the association between RHR and all‐cause mortality ( P interaction < .001) and cardiovascular events ( P interaction =.002). Similar results were observed after exclusion of individuals who died (n = 100) or had a cardiovascular event (n = 45) during the first 2 years of follow‐up. Conclusion High RHR appears to be an independent determinant of all‐cause mortality and cardiovascular events in older but not younger individuals.