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Low Levels of 25‐Hydroxy Vitamin D and Active 1,25‐Dihydroxyvitamin D Independently Associated with Type 2 Diabetes Mellitus in Older Australian Men: The Concord Health and Ageing in Men Project
Author(s) -
Hirani Vasant,
Cumming Robert G.,
Le Couteur David G.,
Naganathan Vasikaran,
Blyth Fiona,
Handelsman David J.,
Waite Louise M.,
Seibel Markus J.
Publication year - 2014
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.12975
Subject(s) - medicine , vitamin d and neurology , diabetes mellitus , epidemiology , endocrinology , population , vitamin d deficiency , gerontology , parathyroid hormone , confounding , body mass index , comorbidity , type 2 diabetes mellitus , type 2 diabetes , renal function , calcium , environmental health
Objectives To examine the associations between serum 25‐hydroxyvitamin D (25 OHD ) levels and the active vitamin D metabolite, 1,25‐hydroxyvitamin D (1,25 OHD ), with type 2 diabetes mellitus ( DM ) in community‐living men aged 70 and older. Design Cross‐sectional. Setting A population‐based, cross‐sectional analysis of the baseline phase of the Concord Health and Ageing in Men Project ( CHAMP ), a large epidemiological study conducted in Sydney between January 2005 and May 2007. Participants Community dwelling men aged 70 and older taking part in CHAMP (N = 1,659). Measurements Serum 25 OHD and 1,25 OHD levels, presence of DM , age, country of birth, season of blood collection, sun exposure, body mass index, vitamin D supplement use, statin use, income, measures of health, depression, activity of daily living disabilities, parathyroid hormone, estimated glomerular filtration rate, phosphate, and calcium. Results The prevalence of DM was 20.0%. There was a significant association between low 25 OHD and 1,25 OHD levels and DM that remained after adjustment for a wide range of confounders and covariates of clinical significance such as comorbidity, renal function, calciotropic hormones, and medications. Conclusion 25 OHD and 1,25 OHD levels were associated with DM . The independent association between serum 25 OHD and 1,25 OHD concentrations and DM raises the question of whether each of the two vitamin D metabolites may influence DM through different biological mechanisms and pathways.