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Proton Pump Inhibitors and Functional Decline in Older Adults Discharged From Acute Care Hospitals
Author(s) -
Corsonello Andrea,
Maggio Marcello,
Fusco Sergio,
Adamo Bakhita,
Amantea Diana,
Pedone Claudio,
Garasto Sabrina,
Ceda Gian Paolo,
Corica Francesco,
Lattanzio Fabrizia,
Antonelli Incalzi Raffaele
Publication year - 2014
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.12826
Subject(s) - medicine , propensity score matching , confidence interval , odds ratio , hypoalbuminemia , observational study , logistic regression , acute care , activities of daily living , physical therapy , health care , economics , economic growth
Objectives To investigate the relationship between use of proton pump inhibitors ( PPI s) and incident dependency in older adults discharged from acute care hospitals. Design Prospective observational study. Setting Eleven geriatric and internal medicine acute care wards located throughout Italy. Participants Individuals (mean age 79.2 ± 5.5) who were not completely dependent at the time of discharge from participating wards (N = 401). Measurements The outcome of interest was the loss of at least one basic activity of daily living ( ADL ) from discharge to the end of follow‐up (12 months). The relationship between PPI use and functional decline was investigated using logistic regression analysis before and after propensity score matching. Results Use of PPI s was significantly associated with functional decline before (odds ratio ( OR ) = 1.75, 95% confidence interval ( CI ) = 1.17–2.60) and after propensity score matching ( OR = 2.44; 95% CI = 1.36–4.41). Other predictors of functional decline were hypoalbuminemia ( OR = 3.10, 95% CI = 1.36–7.10 before matching, OR = 2.81, 95% CI = 1.09–7.77 after matching) and cognitive impairment ( OR = 4.08, 95% CI = 1.63–10.2 before matching, OR = 6.35, 95% CI = 1.70–24.0 after matching). Conclusion Use of PPI s is associated with functional decline during 12 months of follow‐up in older adults discharged from acute care hospitals.