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Association of Inflammation with Loss of Ability to Walk 400 Meters: Longitudinal Findings from the Invecchiare in Chianti Study
Author(s) -
Vasunilashorn Sarinnapha,
Ferrucci Luigi,
Crimmins Eileen M.,
Bandinelli Stefania,
Guralnik Jack M.,
Patel Kushang V.
Publication year - 2013
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.12446
Subject(s) - medicine , quartile , inflammation , prospective cohort study , logistic regression , incidence (geometry) , c reactive protein , cohort , tumor necrosis factor alpha , preferred walking speed , gerontology , physical therapy , confidence interval , physics , optics
Objectives To examine relationships between eight markers of inflammation (interleukin ( IL )‐6, IL ‐6 receptor (R), C ‐reactive protein ( CRP ), tumor necrosis factor ( TNF )‐alpha, TNF receptor 1 (R1), TNFR 2, IL ‐1 receptor antagonist, IL ‐18) and incident loss of ability to walk 400 m. Design Prospective cohort study. Setting Older adults enrolled in the I nvecchiare in C hianti S tudy. Participants Community‐dwelling participants aged 65 and older (N = 1,006). Measurements The eight inflammatory markers were measured at baseline, and an inflammation score was calculated based on the number of inflammatory markers for which the participant was in the highest quartile. Incidence of mobility disability was determined in participants able to walk 400 m at baseline. Logistic regression models were used to determine whether each of the inflammatory markers and the inflammation score predicted loss of the ability to walk 400 m at 6‐year follow‐up. Results After adjusting for covariates, individuals with a TNFR 1 level in each of the highest three quartiles (Q2, 3, 4) were more likely to be unable to walk 400 m at follow‐up than those with TNFR 1 levels in Q1. When adjusting for the same covariates, participants with an inflammation score of 3 or 4 were more likely to become unable to walk 400 m at follow‐up than participants with a score of 0. Conclusion These results provide additional evidence that inflammation is a factor in the mechanisms that cause incident mobility disability and suggest that a combined measure of inflammatory markers may improve prediction of functional prognosis.

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