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Uric Acid Measurement Improves Prediction of Cardiovascular Mortality in Later Life
Author(s) -
Dutta Ambarish,
Henley William,
Pilling Luke C.,
Wallace Robert B.,
Melzer David
Publication year - 2013
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.12149
Subject(s) - medicine , uric acid , hazard ratio , diabetes mellitus , national health and nutrition examination survey , hyperuricemia , confidence interval , population , renal function , cardiology , endocrinology , environmental health
Objectives To estimate the association between uric acid and cardiovascular mortality in older adults, independent of traditional risk factors, and to estimate the risk prediction gain by adding uric acid measurements to the Framingham Cardiovascular Risk Score ( FCRS ). Design Longitudinal observational study of two population‐based cohorts. Setting The E stablished P opulations for E pidemiologic S tudies of the E lderly, Iowa (Iowa‐ EPESE ) and the T hird N ational H ealth and N utritional E xamination S urvey ( NHANES III). Participants One thousand twenty‐eight Iowa‐ EPESE participants and 1,316 NHANES III participants. Selected participants were aged 70 and older without overt cardiovascular disease, renal dysfunction, or diuretic use who lived for 3 years or longer after baseline. Measurements Outcome was age at cardiovascular death during follow‐up (12–20 years). Uric acid and cardiovascular risk factors such as smoking, systolic blood pressure, diabetes mellitus, obesity, serum cholesterol, and high‐density lipoprotein cholesterol were measured at baseline. Results High serum uric acid (>7.0 mg/dL) was associated with male sex, obesity, lipid levels, and estimated glomerular filtration rate at baseline. Fully adjusted hazard ratios ( HR s) for cardiovascular death with high uric acid versus normal were 1.36 (95% confidence interval (CI) = 1.10–1.69) in Iowa‐EPESE and 1.43 (95% CI = 1.04–1.99) in NHANES III; pooled HR was 1.38 (95% CI = 1.16–1.61). The net reclassification improvement achieved by adding uric acid measurement to the FCRS was 9% to 20%. Conclusion In individuals aged 70 and older without overt CVD , renal dysfunction, or diuretic use, serum uric acid greater than 7.0 mg/dL was associated with greater CVD mortality independent of classic CVD risk factors. Adding uric acid measurement to the FCRS would improve prediction in older adults.