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Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study
Author(s) -
Roubaud Baudron Claire,
Letenneur Luc,
Langlais Anthony,
Buissonnière Alice,
Mégraud Francis,
Dartigues JeanFrançois,
Salles Nathalie
Publication year - 2013
Publication title -
journal of the american geriatrics society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.992
H-Index - 232
eISSN - 1532-5415
pISSN - 0002-8614
DOI - 10.1111/jgs.12065
Subject(s) - medicine , dementia , hazard ratio , epidemiology , cohort study , cohort , population , prospective cohort study , risk factor , helicobacter pylori , incidence (geometry) , longitudinal study , gerontology , disease , environmental health , confidence interval , pathology , physics , optics
Objectives To determine whether H elicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population‐based cohort of elderly adults living in the community. Design Prospective community‐based cohort study. Setting The population‐based P ersonnes A gées QUID ( PAQUID ) S tudy. Participants Six hundred three noninstitutionalized individuals aged 65 and older living in the southwest of F rance followed from 1989 to 2008. Measurements A descriptive and comparative analysis including dementia prevalence, according to H . pylori status (serology), was made at baseline. Cox proportional hazard models were used to study the risk of developing dementia according to H . pylori status assessed on sera samples from elderly adults initially free of dementia and followed for 20 years. A neurologist diagnosed dementia according to D iagnostic and S tatistical M anual of M ental D isorders T hird E dition criteria. Results At baseline, 391 (64.8%) subjects (348 women, mean age 73.9 ± 6.5) were seropositive for H . pylori . Dementia prevalence was higher in the infected group (5.4% vs 1.4%, P = .02). After 20 years of follow‐up, 148 incident cases of dementia were diagnosed. After controlling for age, sex, educational level, apolipoprotein E 4 status, cardiovascular risk factors, and M ini‐ M ental S tate E xamination score, H . pylori infection was determined to be a risk factor for developing dementia (hazard ratio = 1.46, P = .04). Conclusion This longitudinal population‐based study provides additional epidemiological support to the hypothesis of an association between dementia and H . pylori infection, which may enhance neurodegeneration.