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Hepatic and renal expression of senescence marker protein‐30 and its biological significance
Author(s) -
FUJITA TOSHIKO,
SHIRASAWA TAKUJI,
INOUE HARUHIKO,
KITAMURA TSUNEO,
MARUYAMA NAOKI
Publication year - 1998
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.1998.13.s1.124
Subject(s) - senescence , ageing , protein expression , medicine , endocrinology , microbiology and biotechnology , biology , biochemistry , gene
A novel rat hepatic protein was detected and isolated, the amount of which is down‐regulated in an androgen‐independent manner with ageing. This protein was designated as senescence marker protein‐30 (SMP30). Senescence marker protein‐30 turned out to be identical to a hepatic calcium‐binding protein called regucalcin (RC). This review gives an overview of SMP30 in its structure, expression and possible physiological function(s). A hypothetical role of SMP30 in ageing and calcium homeostasis is also discussed.