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Immunogenetics of gastrointestinal cancers: A systematic review and retrospective survey of inborn errors of immunity in humans
Author(s) -
Zheng Beishi,
Artin Michael G,
Chung Howard,
Chen Bing,
Sun Siming,
May Benjamin L,
Hur Chin,
Green Peter H R,
Wang Timothy C,
Park Jiheum,
Kong XiaoFei
Publication year - 2022
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.15848
Subject(s) - medicine , cancer , colorectal cancer , common variable immunodeficiency , gastrointestinal cancer , population , retrospective cohort study , oncology , immunology , gastroenterology , antibody , environmental health
Background and Aim Humans with inborn errors of immunity (IEI), or primary immunodeficiencies, may be associated with a potential risk factor for early‐onset gastrointestinal (GI) cancer. Methods We systematically reviewed all cases with clinical diagnoses of both an IEI and a GI cancer in three databases (MEDLINE, SCOPUS, and EMBASE). In total, 76 publications satisfying our inclusion criteria were identified, and data for 149 cases were analyzed. We also searched our institutional cancer registry for such cases. Results We identified 149 patients with both an IEI and a GI cancer, 95 presented gastric cancer, 13 small bowel cancer, 35 colorectal cancer, and 6 had an unspecified cancer or cancer at another site. Gastric and colon adenocarcinomas were the most common. For both gastric and colorectal cancers, age at onset was significantly earlier in patients with IEIs than in the general population, based on the SEER database. Common variable immunodeficiency (CVID) was the most common IEI associated with gastrointestinal cancer. About 12% of patients had molecular genetic diagnoses, the three most frequently implicated genes being ATM , CARMIL2 , and CTLA4 . Impaired humoral immunity and Epstein–Barr virus (EBV) infection were frequently reported as factors potentially underlying early‐onset GI cancers in patients with IEIs. We identified one patient with CVID and early‐onset gastric adenocarcinoma, recurrent diarrhea, and gastrointestinal CMV infection from a retrospective survey. Conclusion Patients with IEIs should be considered at risk of early‐onset GI cancers and should therefore undergo cancer screening at an earlier age.