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Long‐term risk of end‐stage renal diseases with maintenance dialysis among chronic hepatitis C patients after antiviral therapy in Taiwan
Author(s) -
Hsieh MengHsuan,
Bair MingJong,
Tsai PeiChien,
Tseng KuoChih,
Lo ChingChu,
Chen ChiYi,
Kuo HsingTao,
Hung ChaoHung,
Lai HsuehChou,
Peng ChengYuan,
Wang JingHoung,
Chen JyhJou,
Lee PeiLun,
Chien RongNan,
Yang ChiChieh,
Lo GinHo,
Kao JiaHorng,
Liu ChunJen,
Liu ChenHua,
Yan ShengLei,
Lin ChunYen,
Su WeiWen,
Chu ChengHsin,
Chen ChihJen,
Tung ShuiYi,
Tai ChiMing,
Lin ChihWen,
Cheng PinNan,
Chiu YenCheng,
Wang ChiaChi,
Cheng JinShiung,
Tsai WeiLun,
Lin HanChieh,
Huang YiHsiang,
Yeh MingLun,
Huang ChungFeng,
Huang JeeFu,
Dai ChiaYen,
Yu MingLung,
Chuang WanLong
Publication year - 2021
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.15469
Subject(s) - medicine , dialysis , renal function , hepatitis c , hazard ratio , hepatitis c virus , kidney disease , diabetes mellitus , renal replacement therapy , end stage renal disease , hemodialysis , immunology , virus , confidence interval , endocrinology
Background and Aim Chronic hepatitis C virus (HCV) infection is associated with impaired renal function. The aim of this study is to explore the risk of and factors associated with end‐stage renal diseases (ESRD) under maintenance dialysis among HCV patients after anti‐HCV therapy. Methods A total of 12 696 HCV‐infected patients with interferon‐based therapy, including 9679 (76.2%) achieving sustained virological response (SVR), were enrolled from 23 hospitals in Taiwan. Results During a mean follow‐up period of 5.3 years (67 554 person‐years), the annual incidence of 4.1/10 000 person‐years, 4.0/10 000 and 4.7/10 000 person‐years among SVR patients and non‐SVR patients, respectively. History of diabetes and baseline estimated glomerular filtration rate < 60 mL/min/m 2 , instead of SVR, were the significant risk factors for developing ESRD with maintenance dialysis after anti‐HCV therapy (adjusted hazard ratio 7.75 and 9.78). Conclusion Diabetes and baseline impaired renal function were strongly associated with progression to ESRD with maintenance dialysis among chronic HCV‐infected patients after antiviral therapy.