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Epidemiology and risk of psychiatric disorders among patients with celiac disease: A population‐based national study
Author(s) -
Alkhayyat Motasem,
Qapaja Thabet,
Aggarwal Manik,
Almomani Ashraf,
Abureesh Mohammad,
Alotoom Omaymah,
Zmaili Mohammad,
Mansoor Emad,
Abou Saleh Mohannad
Publication year - 2021
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.15437
Subject(s) - medicine , psychiatry , odds ratio , epidemiology , anxiety , population , depression (economics) , cohort study , bipolar disorder , confidence interval , cohort , alcohol abuse , mood , environmental health , economics , macroeconomics
Abstract Background and Aim Celiac disease (CD) is a chronic disorder resulting from an immune reaction to gluten in genetically predisposed individuals. Although several studies have linked CD to psychiatric diseases, there are limited data on this topic. Using a large database, we sought to describe the epidemiology of several psychiatric disorders in CD. Methods We queried a multicenter database (Explorys Inc), an aggregate of electronic health record data from 26 major integrated healthcare systems from 2016 to 2020 consisting of 360 hospitals in the USA. A cohort of patients with a Systematized Nomenclature Of Medicine – Clinical Terms diagnosis of CD was identified. Multivariate analysis was performed using Statistical Package for Social Sciences version 25. Results Of the 37 465 810 patients in the database between 2016 and 2020, there were 112 340 (0.30%) individuals with CD. When compared with patients with no history of CD, patients with CD were more likely to have a history of anxiety (odds ratio [OR]: 1.385; 95% confidence interval [CI]: 1.364–1.407), depression (OR: 1.918; 95% CI: 1.888–1.947), bipolar (OR: 1.321; 95% CI: 1.289–1.354), attention‐deficit hyperactivity disorder (OR: 1.753; 95% CI: 1.714–1.792), eating disorder (OR: 15.84; 95% CI: 15.533–16.154), and childhood autistic disorder (OR: 4.858; 95% CI: 3.626–6.508). Patients with CD and psychiatric conditions were more likely to be smokers, with history of alcohol and substance abuse as well as a history of personality disorder. Conclusions In this large database, patients with CD are at increased risk of having multiple psychiatric diseases including anxiety, depression, bipolar, attention‐deficit hyperactivity disorder, eating disorder, and childhood autism. Individual care and referral to psychiatry when appropriate are warranted while taking care of this group of patients.