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Barriers to hepatitis C direct‐acting antiviral therapy among HIV/hepatitis C virus‐coinfected persons
Author(s) -
Jatt Lauren P.,
Gandhi Malini M.,
Guo Rong,
SukhijaCohen Adam,
Bhattacharya Debika,
Tseng Chihong,
Chew Kara W.
Publication year - 2021
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/jgh.15228
Subject(s) - medicine , odds ratio , medical prescription , hepatitis c virus , confidence interval , hepatitis c , logistic regression , immunology , virus , pharmacology
Background and Aim Direct‐acting antivirals (DAAs) have increased hepatitis C virus (HCV) treatment opportunities for vulnerable HIV/HCV coinfected persons. The aim of this study was to identify the frequency of and potential barriers to DAA prescription in HIV/HCV patients during the first few years of DAA availability in the United States. Methods The AIDS Healthcare Foundation electronic medical record system was queried to identify all HCV viremic HIV‐infected patients in care at AIDS Healthcare Foundation Healthcare centers in January 2015–August 2017 and compare characteristics by receipt of a DAA prescription. Multivariate logistic regression analyses were conducted to examine factors associated with DAA prescription. Results Of 826 eligible patients, 355 (43%) were prescribed a DAA; among those not prescribed a DAA, 301 (64%) had well‐controlled HIV (HIV RNA ≤ 200 copies per mL). In multivariate logistic regression analysis, patients with a history of substance use (odds ratio [OR], 0.51 [95% confidence interval 0.35–0.73]) or on select HIV antiretroviral regimens were less likely to be prescribed a DAA. Those who had well‐controlled HIV (OR, 5.03 [3.06–8.27]), CD4 + T cell count >200 cells per mm 3 (OR, 1.85 [1.04–3.30]), estimated glomerular filtration rate >60 mL/min/1.73 m 2 (OR, 3.32 [1.08–10.15]), or established care prior to January 2015 (OR, 1.57 [1.08–2.29] were more likely to be prescribed a DAA. Conclusions In addition to lack of HIV suppression, select antiretroviral regimens, substance use, and kidney disease appeared to limit DAA prescription in the early interferon‐free DAA era. Many were not prescribed DAAs despite HIV suppression. Further research is needed to determine if the observed associations persist today.